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Safety of first-line bevacizumab plus chemotherapy in elderly patients with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC): M019390 (SAIL) study.

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HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors.

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The Lung Adjuvant Cisplatin Evaluation meta-analysis showed statistically significant benefit of OS and disease-free survival (DFS) for patients who received adjuvant chemotherapy.

In the field of medical research, this is an especially significant example of the use of an inhibitor to treat tyrosine kinase-associated cancer.

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Meier curve of overall survival based on absence or presence of gefitinib treatment is illustrated.

Gefitinib treatment should be interrupted or discontinued if the patient develops severe bullous, blistering or exfoliating conditions.

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Gefitinib is the first selective inhibitor of the EGFR tyrosine kinase which is also referred to as Her1 or ErbB-1.

Skin toxicity induced by gefitinib is common, and has been shown to be related to the inhibition of EGFR signalling pathways.

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Exceptions should be made when using regimens that have a lower chance of causing febrile neutropenia if it is determined that the patient is at high risk for this complication (due to age, medical history, or disease characteristics).

The simultaneous inhibition of these targets therefore reduces tumor vascularization and triggers cancer cell and thus results in tumor shrinkage.

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The prognosis for patients remains poor for those who progress after initial platinum doublet chemotherapy.

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Three days after transfection, the cells were lysed and immunoprecipitated using an antibody against the FLAG-tag and immunoblotted for FLAG and SHP2 ().

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Evaluation of biologic end points and pharmacokinetics in patients with metastatic breast cancer after treatment with erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor.

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